Search results for "human hepatocellular carcinoma cell"

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Nanostructured Lipid Carriers-Containing Anticancer Compounds: Preparation, Characterization, and Cytotoxicity Studies

2007

This article describes the development of nanostructured lipid carriers (NLC) as colloidal carriers for two antitumor compounds that possess a remarkable antineoplastic activity. But their limited stability and low solubility in water could give a very low parenteral bioavailability. Results revealed an enhancement of the cytotoxicity effect of drug-loaded NLC on human prostate cancer (PC-3) and human hepatocellular carcinoma (HuH-6, HuH-7) cell lines with respect to that of both free drugs. Results of characterization studies strongly support the potential application of these drugs-loaded NLC as prolonged delivery systems for lipophilic drugs by several administration routes, in particula…

Materials scienceCell SurvivalDrug CompoundingPharmaceutical ScienceNanoparticleAntineoplastic AgentsPharmacologynanostructured lipid carrierHuman prostatehuman prostate carcinoma cellPlasmaCell Line TumorElectrochemistryHumansParticle SizeSolubilityCytotoxicityChromatography High Pressure LiquidDrug CarriersGeneral Medicineantitumor drugLipidsControlled releaseBioavailabilitySolubilityPlasma chemistryNanoparticleshuman hepatocellular carcinoma cellcontrolled releaseDrug metabolism

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PEPhysical Sciences and Engineering
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